HORDB

ID: hor002343
Uniprot ID: P17685
Protein name: Alpha-bag cell peptide
Gene name: ELH1
Organism: Aplysia parvula (Dwarf sea hare)
Family: Molluscan ELH family
Source: animal
Expression: Bag cell neurons.
Disease: NA
Comments: NA
Taxonomy: Aplysia (genus), Aplysiidae (family), Aplysioidea (superfamily), Aplysiida (order), Tectipleura, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: APRLRFYSL
Length: 9
Propeptide: MGRPSYRSAAAISLLMCLILSALCASSESAVVHGSSFATERAVKSSPYLVLSPADEMVGMSTANEAFDKSPSYYDDDDDDFVKNEKRRLRFHKRRIRFNKRPQEVSGLKPVMMSRASASADENSLFDLYNTDGAMYQRDLRAPRLRFYSLRKRAAGDEDKSEENNPETESHSRRKRSALTPSIRSLRSSLESGIAKRISINQDLKAIADMLIVEQKQEREKYLADLRQRLLNKGKRSSEVALAASDKGDEERELLNTLSNLLE
Signal peptide: MGRPSYRSAAAISLLMCLILSALCASSES
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Decreases the activity of a cluster of neurons in the left upper quadrant of the abdominal ganglion.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: 35 minutes; /2100 seconds ( PubMed ID: 1939259 )

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002343_AF2.pdb

hor002343_ESM.pdb

Mass:	126520	Formula:	C53H83N15O12
Absent amino acids:	CDEGHIKMNQTVW	Common amino acids:	LR
pI:	11.15	Basic residues:	2
Polar residues:	2	Hydrophobic residues:	4
Hydrophobicity:	-5.56	Boman Index:	-1875
Half-Life:	4.4 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	97.78
Instability Index:	7953.33	Extinction Coefficient cystines:	1490
Absorbance 280nm:	186.25